Post 294273 (missing)
(Rhodium: "Cocaine Analogs", Novel Discourse) - In scheme I cocaine is treated with 37% HCl and methanol to give anhydroecgonine methyl ester (that is cocaine without the benzoyl group, and with a double bond between where it was and the carboxymethyl group on the tropane part of the molecule. In Scheme III they proceed from anhydroecgonine methyl ester to 3-phenyltropane by treating it with PhMgBr.https://www.thevespiary.org/rhodium/Rhodium/chemistry/benztropine.txt (https://www.thevespiary.org/rhodium/Rhodium/chemistry/benztropine.txt)
it seems that increased dopamine receptor activity (blocking reuptake) doesn't always mean increased euphoria?