nano and rp/i suck try this instead

[quantum]

well ive tried heaps of rp/i synths and ye they work but
the process is a pain in the arse and all of the tabs
and chems are now watched so why not go for the imine gringnard.

toluene + calcium hypochlorite (paint thiner and pool bleach) --->  benzyl chloride

benzyl chloride + magnesium (fire lighters at desposal store) -----> benzyl magnesium chloride

ethanol + potassium di chromate + sulfuric acid ( metho + photo developing chem + battery acid) ---> acetaldehyde
ethanol + sulfuric acid ---> ether
any of the many methylamine synths I think I will try
to do an Al/Hg on nitro in ether then filter Al(OH)2 sludge
keeping ether/methylamine solution.

methylamine + acetaldehyde ---> acetaldehyde methyl imine

acetaldehyde methyl imine + benzyl magnesium chloride --->
racmic meth major dex minor lev

why waist time making rp/i when in a one litre flask you
can do this and end up with over 100 grams per shot.
high yeilds from what ive read and I have checked all of
these synths out in my orgranic synthises and they all
seem to check out nice.
maby its time to leave these stupid fucking pills alone
and do some real chem.

[lugh]

You're right in stating it all makes sense, but none have reported success but L_L, and many others have tried    One flaw in your proposed synthesis is that magnesium fire starters aren't pure enough for a grignard, you would have to form the chloride, purify it and use the OS method to prepare the Grignard reagent  

[ChemoSabe]

[quantum]

so I have to get it from a chem supply place damb.
any way that I can tell if the fire magnesium is good or not
ive seen a few different types around.
maby if I used lithium instead and did the gringrnard in
dry ice instead then I can make the lithium pure as from
lithium carbonate

[jemma_jamerson]

ethanol + potassium di chromate + sulfuric acid ( metho + photo developing chem + battery acid) ---> acetaldehyde

+toluene ---> benzaldehyde (ha just found a funny link

http://www.faizkaskar.8k.com/proj.htm

on MANUFACTURE OF BENZALDEHYDE BY LIQUID PHASE CHLORINATION OF TOLUENE..)

for the bio synth of l-pac..then catalytic hydrgenation---->meth

[frosted]

If you have a way to get pure magnesium, is this synthesis possible?  Is the magnesium purity the only problem with this synthesis?  There is a factory close by that produces products made of magnesium, so swim could get some scraps from there and use that.  Unless there is something else wrong with this process as well.  Any insights?

[RepVip]

My two cents:
You should have a way easier time obtaining LG magnesium than making your own diethyl ether...
Also you would need some practical lab experience and the proper glassware (of course) to do most of the synths you suggest. Its not as easy as it sounds, however, I am in total agreement that this is a better way than the mbrp/I(tincture), at least for some.

[Organikum]

you would have to form the chloride, purify it and use the OS method to prepare the Grignard reagent

Assuming that "OS" stands for Osmium and the "chloride" refers to  magnesium, I did a search for this method using "grignard" and/or "MgCl" etc. but came up with nothing.
Can you point me to this please?

thanks
ORG

[lugh]

OS is an abbreviation for Organic Syntheses, see

Post 448168 (missing)

(WizardX: "GRIGNARD AND RELATED REACTIONS", Stimulants)  

[Organikum]

me stupid    

Actually my first guess was "Operating System" - must be related to my profession...

thanks
ORG (not synthetic)

EDIT
But following this links shows me ALL Grignard reactions at Org.Synth. what is nice but not new to me. Sadly it answers in no way the question on WHICH Org.Synth. procedure was talked about. The one link provided by WizardX which MIGHT have been it "preparation..." leads to nowhere....
Sad but true.

"Da steh ich nun ich armer Thor and bin so klug als wie zuvor..."
Goethe, Faust.  

[skanic]

hello,
what is the yield of the benzyl magnesium chloride synthesis, if BzCl and Mg are pure ?
can we use an other solvent than diethyl ether ?

[quantum]

as usual give em a bone and they want ya leg
well as far as can it be done in other solvents the answer is yes and maby you would have benifeted more by reading
the gringnard links lugh produced becouse then you would
know why. this attitude that a lot of the hive has kills me
the only question we should be asking is why is that not
what science is about why use ether for a solvent.
come up with that answer and you will find that you can
use THF or even dibutylether.
I have heard rumours of being able to do the second part
of the gringnard in an aromatic solvent but the first
part to my belife is catylized by the oxygen in the ether.
so to answer correctly yes and no. but then if you were
interested in chemistry and not your nose and pocket
you would have known that.
yes this works yes lugh is right about the firestarters
and yes it is easier to buy somthing from a shop than
to synth ether. but if you cannot synth ether what the
fuck are you doing making drugs for human consumption.
this place is a freedom but dont ever forget it is also
a responsability.

now for another idea (not mine just puting it in everyones
face)

toluene + hypochlorite ----> benzylchloride
potassiumferricyanide + sulfuric acid ----> hydrogen cyanide
hydrogen cyanide + sodium hydroxide -----> sodium cyanide
benzylchloride + sodium cyanide -----> benzylcyanide
benzylcyanide + sulfuric acid ----> phenylacetic acid
acetone via pyrolysis -----> keten
keten + water ----> acetic acid
acetic acid + keten -----> acetic anhydride
phenylacetic acid + acetic anydride with a dash of sodium acetate ----> phenyl-2-propalacetone

potasium ferricyanide is used for photography and blue prints.

be warned hyrogen cyanide and keten are fucking deadly.
SO DONT TELL ME I FUCKING KNOW.


peace all and keep reading rp/i'ers your time is nearly up
and thank fuck for that

[skanic]

thank you quantum

[stereoIsomer]

Thanks for teeing up this pathway, quantum. I was told (by someone who knows, 2+ years ago) that meth was being synthesized industrially in the Americas via Toluene as initial building block. So, it should be encouraging to know that it's being done successfully as a large scale process this way. Whatever i can find out further about details, I will certainly post.

The note on TOLUENE:::
On the left-coast, some large DO-IT-YO-self supply warehouses no longer carry TOLUENE. Whilst shopping in the PRO SHOP of one of these orange & black behemoths, I was told by the floor-hand that Toluene's role in drug synthesis was the reason it is no longer on shelves.
Fortunately the asian hardware store up the street sees no such conflict of interest- so at least it's not law out here. Nonetheless, this could be a trend and as always, be careful buying- it's possible to track (solvent) purchases over time to individuals, if for no other purpose than 1:1 marketing / data-mining........

peace!

[frosted]

So is this all theory?  Or can this actually be done? Has anyone tried it yet?

[WizardX]

GRIGNARD AND RELATED REACTIONS

http://www.orgsyn.org/orgsyn/RxnTypes/section.asp?section=117

HIGHLY REACTIVE MAGNESIUM FOR THE PREPARATION OF GRIGNARD REAGENTS

http://www.orgsyn.org/orgsyn/prep.asp?prep=cv6p0845

n-PROPYLBENZENE, C6H5CH2CH2CH3

http://www.orgsyn.org/orgsyn/prep.asp?prep=cv1p0471

Catalytic Dehydrogenation
C6H5CH2CH2CH3 ==[-H2]==>> C6H5CH=CHCH3

[quantum]

nice on wizard so now onto making potassium
do you think that K will strip Mg of a sulfate ion
as well as the chloride?

[quantum]

no can do only halides intersting that you can use Na as
well

[ahgreich]

Benzaldehyde + MEK acid catalyzed aldol
simplest route to P2P that sb had seen lately. nothing foul like ketene or benzylchloride.

[quantum]

but I am not so sure on the yeild of the beayer villiger oxidation. it all looks great untill you need some funky
oxidizing agent to get over 30% yeild yucky

just did the first step benzylchloride from toluene well
its running now everythings sweet used 200g of hypochorite
and an excess of toluene hoping not to get any di and tri
halides cooking it on a water bath and there is no risk of
explosion or fire.
I have kept the temp of the water at around 95 C so as not
to loose heaps of water (im not in the lab at the moment)
and there are lots of little bubbles all over the place inside the flask, very smooth indead
will let you know how I go and post yeild based on hypo
tomorrow boiling battery acid then NaCN from ferricyanide
if I dont post nice knowing ya all.