Synthesis of N-Alkyl-N-Hydroxyamphetamines and Related Nitrones
A. H. Beckett, R. T. Coutts and F. A. Ogunbona
Tetrahedron 29, 4189-4193 (1973) (https://www.thevespiary.org/rhodium/Rhodium/pdf/n-oh-amphetamines-1.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/n-oh-amphetamines-1.pdf)
Abstract
The action of m-chloroperbenzoic acid on various amphetamines and on dibenzylamine is shown to yield N-hydroxy derivatives and related nitrones.
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Synthetic Routes to Optical Isomers of Primary and Secondary Hydroxylamines of 1-Arylisopropylamines
A. H. Beckett, K. Haya, G. R. Jones and P. H. Morgan
Tetrahedron 31, 1531-1535 (1975) (https://www.thevespiary.org/rhodium/Rhodium/pdf/n-oh-amphetamines-2.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/n-oh-amphetamines-2.pdf)
Abstract
A number of optically pure primary 1-arylisopropylamines were converted to 3-phenyl-2-(1'-arylisopropyl)oxaziridines by the oxidation of the corresponding benzylamines with m-chloroperbenzoic acid. Subsequent acid hydrolysis of the 3-phenyloxaziridines yielded optically pure N-hydroxy-1-arylisopropylamines. The action of m-chloroperbenzoic acid on optically pure secondary 1-arylisopropylamines gave optically pure N-hydroxy derivatives. The optical purity of the hydroxylamines were analysed by GLC utilizing N-trifluoroacetyl-L-prolyl chloride as a reagent.
Excuse my typo, I have added a correction to Post 532000 (https://www.thevespiary.org/talk/index.php?topic=11621.msg53200000#msg53200000)
(Rhodium: "Methoxamine is no good precursor.", Novel Discourse)
Even if the ephedrine-DMA route you propose worked w/ RP/HI, it wouldn't bee cool to bee ripped-off by pharmaceutical companies and extract the precursor from thier shitty tablets for this synthesis...
But, if you really like that route read: Post 504623 (https://www.thevespiary.org/talk/index.php?topic=12211.msg50462300#msg50462300)
(Kinetic: "Another way to methaephetamine", Novel Discourse)