Post 214369 (missing)
(foxy2: "2 Bromination of 3,4-dimethoxybenzaldehyde", Chemistry Discourse) gives synthesis of 2,4,5 aldehydes. If SWIMs presentation works, chemist will not have to keep a methoxy, but can change it even when it was from nature.Post 58487 (https://www.thevespiary.org/talk/index.php?topic=11651.msg5848700#msg5848700)
(psychokitty: "Has psychokitty won the OTC safrole contest?", Novel Discourse)Post 71298 (missing)
(startinout: "has startinout won the OTC safrole comp?", Novel Discourse)Post 477628 (https://www.thevespiary.org/talk/index.php?topic=8829.msg47762800#msg47762800)
(Rhodium: "Vanillin to Protocatechualdehyde (AlCl3/Py)", Methods Discourse)Post 172095 (missing)
(dreamer: "cleavage of methoxy group from vanillin", Chemistry Discourse)
Some of the more notable are the boron trihalide-dimethylsulfide complexes which are stable and can be safely handled at room temperature.
This is very good, thank you again terbium.
http://patft.uspto.gov/netahtml/srchnum.htm (http://patft.uspto.gov/netahtml/srchnum.htm)
My comment to all that is still the same: H2SO4.
Fuck the yield, eugenol is cheap and most bees would prefer a lower yielding OTC procedure over anhydrous compounds which can only be had from chemical suppliers. When you consider the amount of chems needed I'm even sure that the H2SO4 procedure will be much cheaper, even if it produced only 30% or so yields.
You are the one who posted this, no? If you are interested there is alkaline hydrolysis to. You are interested in synthesis of safrole?? SWIM thinks this procedure is much useful for other things than safrole. It would not be effcient(?) to use this for safrole when there is so much of it from other places.
Ethylvanillin would be good for synthesis of compound that Shulgin calls Meta-Escaline. A chemist could maybe bridge a methylenedioxy ring to make a ethylated version of MMDA. Not very interesting.
It would not be effcient(?) to use this for safrole when there is so much of it from other places.
Dear Masquerade! It just happens so that i live in a place where the closest safrole one can get is in 5000 km range :-[ - as well as many, many other things without which a normal chemist wouldn't even consider working - not that i'm a real chemist, but you get what i mean...
And this IS the 1st procedure i've ever seen that uses none of these things.
So - first - i want to thank you very much for this procedure, thank you!
And second - i'm very interested in that alkaline hydrolysis procedure, PLEASE, post if you would.
Because,
My comment to all that is still the same: H2SO4.
Fuck the yield, eugenol is cheap and ...
Naturally, H2SO4 hydrolysis won't bee suitable for eugenol because of its double bond, will it? Whereas it should bee pretty stable to alkali in inert atmosphere - please, correct me if i'm wrong.
Respects,
Antoncho
Post 274314 (https://www.thevespiary.org/talk/index.php?topic=7089.msg27431400#msg27431400)
(3base: "Re: Cleavage of Alkoxy group to give Phenol", Chemistry Discourse)Synthetic Communications, 31(6), 869–875 (2001) (https://www.thevespiary.org/rhodium/Rhodium/pdf/ether.cleavage.zn-nicl2.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/ether.cleavage.zn-nicl2.pdf)