Author Topic: Essential Opioids  (Read 25220 times)

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Essential Opioids
« on: July 29, 2004, 01:19:00 AM »
Synthesis and Analgetic Activities of Some Aminobenzylcyclanols Derived from Menthone
Özarslan, Ö. et al.
Arch. Pharm. (Weinheim) 327, 525-528 (1994)


Several cyclohexanamines such as Tilidin, Tramadol, and Ciramadol have been used as opiate analgesic drugs. Here, we describe synthesis and analgesic activity of some aminocyclanols from (-)-menthone (1R,4S-1-methyl-4-isopropyl-cyclohexan-3-one).

Two synthetic routes are described for the preparation of amino-benzylcyclanols and related derivates: One is the reaction of alpha-benzylcyclanols. In the other approach, benzisoxazols are first formed from benzylnitrones and cycloalkene, then treatment of benzisoxazoles with an allyl-halide produces the corresponding benzoxazoline halide and hydrogenolysis of these halides give the desired compounds.

(Used TFSE for this one too, and couldn't find it. Hoping it's not hidden somewhere deep inside the hive...)


  • Guest
that looks easy
« Reply #1 on: July 29, 2004, 12:42:00 PM »
Intersting to read that with some of the synthesized compounds, if they are administered for 5 days and then the animals are subjected to a naloxone challenge there is no withdrawal.

Does anybody know if it is likely that these compounds have any euphoriant qualities? Is it likely that those that do not induce withdrawal are not as euphoric (just skeptical as you rarely get something for nothing in this world).


  • Guest
Benzomorphans do not have nearly the physical...
« Reply #2 on: August 20, 2004, 04:03:00 AM »
Benzomorphans do not have nearly the physical addiction potential and they can be very fun~ phenazocine, metazocine....

I'd really like to experiment with O-acetyl phenazocine one day.  I've heard conflicting arguements on whether it would have any difference in effect.

(Hi y'all, it's been a while....)