Just got my issue of
Discover today... interesting popular-language overview of ibogaine and its cogener, 18-methoxycoronaridine.
18-MC, according to the article, presents some of the addiction-quelling properties of ibogaine without ibogaine's side effects. Don't know if this would be of use to anyone... I am still teaching myself o-chem and thought someone may wish to try and synth/taste/research this. A WebCrawl for 18-methoxycoronaridine found this blurb:
...18-methoxycoronaridine exerts its anti-addictive effects via a reversal of the neuroadapations mediating increased incentive salience for drugs of abuse...
Maybe in addition to its apparent anti-addiction potential, could it be used by hedonists (read: people like me) to resensitize the CNS to 5-HT-ergic and DA-ergic (read: almost any enjoyable) drugs?
The article:
Abrams, Michael. "The End Of Craving." Discover May 2003 (vol. 24 : no. 5) pgs 24-5.
Page of citations of 18-MC research:
http://www.ibogaine.org/18-mc/