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I have found this completely strange stimulant. In medline no other reference.. The only thing I know is that is related to piracetam (from the abstract below i suspect it is close to aniracetam or nefiracetam) and have heard it has some interesting psychostimulant properties.. Any chemical structure or bioassay report would be useful to cease my(our) itching curiosity..
Analyst. 1999 Nov;124(11):1559-62
" Determination of carphedon in human urine by solid-phase microextraction using capillary gas chromatography with nitrogen-phosphorus detection. "
Kim S, Park JH, Myung SW, Lho DS.
Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea. skkim@kist.re.kr
Carphedon is a phenyl derivative of nootropil and is effective in increasing physical endurance and cold resistance, and is used for amnesia treatment. Carphedon was extracted from human urine samples by solid-phase microextraction with a 65 microns carbowax-divinylbenzene-coated fiber. This analysis was performed by using capillary gas chromatography with nitrogen-phosphorus detection and optimized at pH 9.6, 30% NaCl, immersion time 10 min and desorption in the GC injector at 250 degrees C for 3 min. The regression equation for carphedon showed good linearity in the range from 0.1 to 10 micrograms ml-1 for human urine samples. The limit of detection was 0.01 microgram ml-1. The developed method is more sensitive and simpler in sample preparation than liquid-liquid extraction and can be applied to doping analysis for stimulants.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10746314 (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10746314)
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What does its structure look like?
http://www.springerlink.com/openurl.asp?genre=article&id=doi%3A10.1007/s001940050113 (http://www.springerlink.com/openurl.asp?genre=article&id=doi%3A10.1007/s001940050113)
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The above article is available online, free of charge:
Determination of carphedon in human urine by solid-phase microextraction using capillary gas chromatography with nitrogen-phosphorus detection
Seungki Kim, Joon-Ho Park, Seung-Woon Myung and Dong-Seok Lho, Analyst 124(11), 1559-1562 (1999)
DOI:10.1039/a906027h (http://dx.doi.org/10.1039/a906027h)
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Thanks Chief-Bee for the enlightment..
We have another designer drug...
Interesting seems to be. Finally we know where to search for the synthetic route.
Russian journals? Hhmm! Tough to find..But thats why we live in the Hive-village !
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Reactant: 3-phenyl-4-ureido-butyric acid
Product: 2-oxo-4-phenyl-pyrrolidine-1-carboxylic acid amide
Reagent: acetic anhydride
Time: 1 hour
Other Conditions: Heating
Yield: 93%
Avetisyan, S. A.; Korachov, S. L.; Azaryan, L. V.; Karapetyan, A. A.; Struchkov, Yu. T.
Chem. Heterocycl. Compd. (Engl.Transl.); 31(1), 28-32 (1995)
Khim. Geterotsikl. Soedin. 1, 33-38 (1995)
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See
Post 397796 (missing)
(pHarmacist: ""Russian Designer Drug" (?)", General Discourse) --> Post 402840 (missing)
(Rhodium: "Ref for preparation of Phentropyl (Korphedon)", General Discourse).
Carphedon, Korphedon, Phentropyl, and Phenotropyl are synonyms. At least, Russian medicinal web pages say so.
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Thanks bros.. Now the picture is complete..
Rhodium: Deja-vu for you !
From what I can see, it is definitely a study aid, although SWIM must make a bio-assay soon to estimate its pure CNS stimulant properties..