The Vespiary

The Hive => Chemistry Discourse => Topic started by: acx01b on October 25, 2004, 06:48:00 PM

Title: very OTC Amph et MethAmph synths
Post by: acx01b on October 25, 2004, 06:48:00 PM
after reading:

https://www.thevespiary.org/rhodium/Rhodium/chemistry/benzylchloride.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/benzylchloride.html)


https://www.thevespiary.org/rhodium/Rhodium/chemistry/meth.phenylacetaldehyde.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/meth.phenylacetaldehyde.html)



Toluene is refluxed with dried Ca(ClO)2 to yield BenzylChloride by decantation

Benzylchloride is reacted with Magnesium in very dried diethylether and 2-3mg of iodine to yield BenzylMagnesium Chloride

Acetone is reacted with Ethylamine and microwaved-powdered MgSO4 to yield by phase decantation AcetoneEthylimine

AcetoneEthylimine and BenzylMagnesium Chloride are refluxed to yield after hydrolysis Alpha-Methyl-N-Ethyl-amphetamine (methamphetamine like)
Title: Ethamphetamine
Post by: indole_amine on October 25, 2004, 07:11:00 PM
Chemistry sounds alright, but N-ethyl-amphetamine is only half as potent as regular amphetamine...


indole_amine
Title: The product wouldn't be N-ethylamphetamine but
Post by: moo on October 25, 2004, 07:35:00 PM
The product wouldn't be N-ethylamphetamine but N-ethylphentermine.

Title: reason?
Post by: indole_amine on October 25, 2004, 07:48:00 PM
I guess for n-ethyl-amphetamine one would have to use rather acetaldehyde instead of acetone. Correct?


indole_amine
Title: it is quite cross-posting but if acetaldehyde...
Post by: acx01b on October 25, 2004, 08:41:00 PM
it is quite cross-posting but if acetaldehyde is available, this way is cool too:
Ph-CH2-MgCl + CH3CHO --> Ph-CH2-COH-CH3
Ph-CH2-COH-CH3 + H2SO4(90%)/NaCl --> Ph-CH2-CCl-CH3
Ph-CH2-CCl-CH3 can be extracted very easily (phase separation, toluene should work)
then it is reacted with hexamine (pharmacy store)
Title: The reaction of benzylmagnesiumchloride with...
Post by: Bandil on October 25, 2004, 09:37:00 PM
The reaction of benzylmagnesiumchloride with acetaldehyde will not yield p2pol in any desirable yields. The product will rearrange to something useless (cant remember what), but there are loads of descriptions in TFSE about this...