Author Topic: Synth of Ephedrine from protected Cyanohydrins  (Read 2051 times)

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Synth of Ephedrine from protected Cyanohydrins
« on: February 01, 2003, 08:01:00 AM »
Stereoselectrive Syntheses of Ephedrine and Related 2-Aminoalcohols of High Optical Purity from Protected Cyanohydrins
Jackson et al

Tetrahedron Letters, 31, 10, 1447-1450 (1990)

(https://www.thevespiary.org/rhodium/Rhodium/pdf/ephedrine.grignard.pdf)

Abstract:
Ephedrine and related optically active b-aminoalcohols can be prepared by zinc borohydride reduction of aryl O-protected magnesium imines and aryl a-hydroxyimimes which in turn are readily available from optically active cyanohydrins.