The Hive > Novel Discourse
Rhodium:
Animal Pharmacology and Human Psychopharmacology of 3-Methoxy-4,5-Methylenedioxyphenylisopropylamine (MMDA)
A.T. Shulgin, T. Sargent and C. Naranjo
Pharmacology 10, 12-18 (1973) (https://www.thevespiary.org/rhodium/Rhodium/chemistry/mmda.pharmacology.shulgin.html)
Abstract
A rationale is presented for the investigation of the synthesis and pharmacology of 3-methoxy-4,5-methylenedioxyphenylisopropylamine (MMDA) as a potential psychodysleptic compound; these experiments are reported. The chemical synthesis and physical properties of this compound are described. The pharmacologic effects of MMDA in several animal species are presented, as are its clinical effects in man. The animal pharmacology was generally unremarkable, except for a hypotensive effect in the dog, and the therapeutic index (LD50 rat/MED50 human) was 85. The subjective effects of MMDA in man include an enhancement of feeling and of eyes-closed visual imagery, but no hallucinogenesis or other disturbance of the sensorium. Reality testing and environmental contact are not affected except for a tendency to withdraw into a state of drowsiness, or into a world of fantasy and visual imagery. The induced state of increased availability of emotion was easily manipulated in the psychotherapeutic setting used, and appeared to lead to an enhanced insight into subconscious content.
Rhodium:
Potential Misrepresentation of 3,4-Methylenedioxyamphetamine (MDA). A Toxicological Warning.
Alexander T. Shulgin & Peyton Jacob III
Journal of Analytical Toxicology, Vol 6, 71-75 (1982) (https://www.thevespiary.org/rhodium/Rhodium/pdf/shulgin/shulgin.piperonylacetone.pdf)
Abstract
The illicit synthesis of the popular drug 3,4-methylenedioxyamphetamine (MDA) has frequently called upon the precursor piperonylacetone, which is reductively aminated with ammonium hydroxide. The term "piperonylacetone" has been used for two distinct chemical entities in the chemical literature, viz. 3,4-methylenedioxyphenylacetone or 3,4-methylenedioxybenzylacetone. It is only the first of these two chemicals which will give rise to MDA. The second chemical has been made commercially available as piperonylacetone and, employing the usual recipes, produces 1-(3,4-methylenedioxyphenyl)-3-aminobutane. This amine could be mistaken for MDA if only simple presumptive tests are employed. This latter base is largely unexplored pharmacologically and toxicologically and, as it may reasonably appear in illicit drug traffic misrepresented as MDA, it may well represent a clinical problem of unforseeable consequences.
hypo:
> https://www.thevespiary.org/rhodium/Rhodium/chemistry/mmda.pharmacology.shulgin.html
after having experienced different dosages with different people,
a foaf acknowledges all points in this article except point #6:
no subject has ever expressed anxiety at all. on the contrary, they
all found themself in a wonderful bodyspace. the probable explanation
is that the subjects in the article were in a psychotherapy setting.
the visions are everyday things, but there is no apparent meaning -
no problems force themselves into the foreground, although one certainly
could if one wanted. this makes the drug very special in that there is
no push. it's like letting one's subconsciousness be on the loose.
other observations:
* on high dosages (400+, in two doses) there are definite OEVs. the
kind of where there's no relation between what is seen and what is there
and which take quite some focussing effort to see what's really there.
* even on high dosages there is practically no body load
* excess alcohol intake has a bad effect on the visions. what used to be
visions turn into dreams not unlike nodding off from opiates.
all in all: a pretty unique drug. but probably nothing for the
"fuck my mind harder"-crowd.
Rhodium:
Psychotomimetic Agents Related to Mescaline
Alexander T. Shulgin
Experientia 19, 127-128 (1963) (https://www.thevespiary.org/rhodium/Rhodium/chemistry/mescaline.analogs.shulgin.html)
____ ___ __ _
Psychotomimetic Amphetamines: Methoxy 3,4-Dialkoxyamphetamines
Alexander T. Shulgin
Experientia 20, 366-667 (1964) (https://www.thevespiary.org/rhodium/Rhodium/chemistry/shulgin.meo-34-dialkoxyamphetamines.html)
(kudos to lugh for retrieving copies of these)
Rhodium:
Study of the Central Nervous Activity and Analgesia of the N-Substituted Analogs of the Amphetamine Derivative 3,4-Methylenedioxyphenylisopropylamine
Braun, U., Shulgin, A. T., and Braun. G.
Arzneimittel Forschung/Drug Research, Vol. 30(1), No. 5, 825-830 (1980) (https://www.thevespiary.org/rhodium/Rhodium/pdf/shulgin/shulgin.n-alkyl-mda.analgesics.pdf)
Summary
N-Substituted analogs of 3,4-methylenedioxyphenylisopropylamine (MDA) were tested for analgesic potency and influence on motor activity in mice following oral administration. These compounds also were tested for their psychotomimetic potency in man. Unsubstituted MDA and its monoalkyl homologs with a low number of C-atoms (N-methyl-, N-ethyl-MDA) showed both enhancement of motor-activity in mice and psychotomimetic effects in man. MDA and N-methyl-MDA also showed an analgesic effect which was enhanced by the inclusion of a weakly basic group (N-allyl, N-hydroxyethyl). These latter two compounds, however, did not influence motor-activity, which makes them more recommendable as possible analgesic compounds. Structural parallels between these compounds, morphine, endorphins and enkephalins, may explain their similar spectrum of pharmacological effects.
(Kudos to 'legal' for fetching the article!)
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