Patent CH254106 (http://l2.espacenet.com/dips/viewer?PN=CH254106&CY=gb&LG=en&DB=EPD)
Patent CH252755 (http://l2.espacenet.com/dips/viewer?PN=CH252755&CY=gb&LG=en&DB=EPD)
Patent CH253710 (http://l2.espacenet.com/dips/viewer?PN=CH253710&CY=gb&LG=en&DB=EPD)
http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=CH254106 (http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=CH254106)
instead (change the trailing numbers to access the other patents)Post 507952 (https://www.thevespiary.org/talk/index.php?topic=9082.msg50795200#msg50795200)
(Rhodium: "Swiss Levorphanol Patents", Methods Discourse) was the route used by Hoffmann-LaRoche, at least a few decades ago. Even if you don't know german you can at least follow the reaction sequence by the illustrations provided.
Sounds sweet, eh? Hard to say, how well the conversion from octahydro-isoquinoline/10-hydroxy-decahydroisoquinoline to morphinan really works, but it does look possible!Quote
Have you looked into this anymore? I mean, do you think it works as well as one would think, or is it plagued with tons of problems that makes the reactions fail and or produce low-yields?
Just curious.
Anywho, thanks!