The Vespiary
The Hive => Newbee Forum => Topic started by: aleph on October 28, 2003, 12:27:00 AM
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Anyone have a clue whether sodium borohydride rather than sodium cyanoborohydride will work in Strike's (Total Synthesis II) method #1 (page 98)?
A post I have seen indicates it may be a possibility, but indicates the use of methylamine gas. I was hoping for the easy reaction in Strike's book without cyanoborohydride.
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Borohydride will work with methylamine just fine althought cyanoborohydride will give slightly higher yields(it doesn't reduce ketone to alcohol,which borohydride does,but only imine to amine).
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Thanks for the info.