Its weird how it seems like Shulgin gave up on the DPT derivatives so quickly. His research showed it to be active orally in >100mg range. He vaguely documented 4-HO-DPT and reported only one test at 20mg level to be a possible threshold dose. 5-MeO derivatives show an increased potency (up to x10) that is attributed to the substance more effectively crossing the blood brain barrier. Shulgin seemed to have a field day making 5-MeO analogues of everything except DPT.
I always get the feeling somebody is hiding something, if you know what I mean. *Wink wink, nudge nudge*
Upon further investigation we can find Shulgins research regarding 5-MeO-DPT hidden at the bottom of the 5-MeO-DET section. The method discussed (aswell as the DPT synth) seem reminiscent of the diisopropylation of DiPT and 5-MeO-DiPT, except he's using IPA instead of the dreaded Sulfolane making this a rather straightforward procedure.
Shulgin goes on to say, "TLC analysis at this time showed the presence of both the mono- and the dialkylamines, but there was no indication of the presence of unreacted 5-methoxytryptamine or of the quaternary salt." He then proceeds to perform lengthy extractions to isolate 5-MeO-DPT. I believe the extraction procedure can be simplified, furthermore the precursors are relatively easy to acquire or produce. Here's what I'm thinking on a nanoscale:
2.8 mL diisopropylethylamine and 1.5 mL propyl iodide are taken up in a warm solution of 900 mg 5-methoxytryptamine in 10 mL IPA, and the mixture was heated on the steam bath for 5 h. Solvent is distilled and residue is diluted with 25 mL H2O. 2.5 mL 5% aqueous NaOH is added to produce a cloudy suspension that is extracted with 30 mL hexane. Colorless oil is recovered via distillation of solvent. 490 mg freebase is dissolved in 3 mL IPA and neutralized with 0.5 mL HCl. Crystallization is instigated with Et2O. Product is removed by filtration. Crystals washed with 4:1 IPA / Et2O mixture. Product is air dried to yield 540 mg 5-methoxy-N,N-dipropyltryptamine hydrochloride.
-Zen
