I feel like a pariah. Oh, rejection, how bitter. Have I fucked up that much, guys?
In the reduction amination of MDP2P with NaBH4, where 0.25mol borohydride is the theoretical lower limit (I assume it donates all four H+) and LaBTop's write-up using 0.47 mol NaBH4 per mol of ketone works like a charm, what would be the lower limit before yields suffer? All just theoretical information, of course. Will the use of 0.38 mol boro per mol of ketone suffer reduced yield? Anybody know? I wouldn't want to have to experiment, the procedure is not looked kindly upon by the local authorities.