What few people know is that fentanyl is actually less addicting. The withdraw is not as tough as with morphine / heroin, probably because the dose is so small (and because it is not as good).This also in contradiction with what has been written in post
Post 347651 (missing)
(raffike: "Actually fentanyl and it's analogues cause harder ...", General Discourse):
Actually fentanyl and it's analogues cause harder addiction than H cuz it's said to be better than ol' brown H
I just wanted to straighten this out. Again, just because a compound is more powerfull (lower ED
50) it doesn't necessarily imply that it is better and / or more addictive.
Furthermore, p-fluoro-fentanyl seems to be more morphine like than fentanyl.
The order of receptor affinity of morphine is mu > delta > kappa, whereas in fentanyl and sufentanil the order is somewhat reversed (mu > kappa > delta). p-fluoro-fentanyl has the same order of binding affinity to the receptors as morphine, with the only difference that it binds
49 x stronger to the mu receptor,
7 x stronger to the delta receptor,
and 5 x stronger to the kappa receptor
than morphine.
For comparison, fentanyl binds
7 x stronger to the mu receptor,
0.9 x stronger to the delta receptor,
and 2.8 x stronger to the kappa receptor
than morphine.
And sufentanil binds
24 x stronger to the mu receptor,
3.7 x stronger to the delta receptor,
and 14 x stronger to the kappa receptor
than morphine.
So, p-fluoro-fentanyl is stronger than sufentanil.
And o-fluoro-fentanyl is even stronger than the para isomer. That compound would blow the crap out of you, even by looking at it ...
Who said p-fluoro-fentanyl is weaker than fentanyl ... hmm let me see.
Maintenant, je suis cassé
ggrrrrrr ...