A One-Pot Process for the Enantioselective Synthesis of Amines via Reductive Amination under Transfer Hydrogenation Conditions
Glynn D. Williams, Richard A. Pike, Charles E. Wade, and Martin Wills
Organic Letters, 5(22), 4227-4230 (2003) (https://www.thevespiary.org/rhodium/Rhodium/pdf/redamin.cth.boc-amines.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/redamin.cth.boc-amines.pdf)
DOI:10.1021/ol035746r (http://dx.doi.org/10.1021/ol035746r)
(https://www.thevespiary.org/rhodium/Rhodium/hive/hiveboard/picproxie_docs/000466787-file_5rbi.gif)
Abstract
Cyclic amines may be prepared via a sequence of deprotection followed by intramolecular reductive amination of t-Boc-protected amino ketones under asymmetric transfer hydrogenation conditions. In cases where the corresponding imine reaction proceeds with high enantioselectivity, this is reflected in the one-step process.