we report here a very simple, fast and general method for knoevenagel condensation. ...
general procedure: methylene compound 1 and carbonyl derivative 2 were mixed together at r.t., without solvent in amounts given in table 1 in an erlnemeyer flask (10 to 100mL). the appropriate volume of piperidine, which may be adjusted accordung to the weight of reactants, was then added (see table 1). the mixture was subjected to microwaves for an optimized time and power. the solid product was washed with MeOH/Et2O, EtOH or MeCN. the crude oil was purified by short-path distillation. the shape and size of the reaction vessel are important factors for the heating of dielectrics in a microwave oven.
synthesis 1994, 258-260 "minute synthesis of electrophilic alkenes under microwave irradiation" s abdallah-el ayoubi, f texier-boullet, j hamelin
methylene compound = EtNO2, MeNO2 and others carbonyl derivative = several benzaldehydes
the catalytic amounts of piperidine, needed for this reaction can be prepared from pepper
even if the MDA/MDMA and mescaline precursors: 3,4-methylenedioxyphenyl-2-nitropropene 3,4,5-trimethoxy-beta-nitrostyrene are not named explicitly, they should definitively be accessible through this procedure.
Title: This one is related too: http://www.rhodium.
Post by: Rhodium on June 06, 2002, 04:21:00 AM