Column chromatography of psilocybin!

[Bandil]

Hi!

Swim was thinking it would be really cool to have >95% pure psilocybin crystals lying around, as they are quite pretty. Now the mushrooms contain a lot of different alkaloids, that are quire hard(impossible) to separate, by simpel A/B. What about column chromatography:

1) Is silica gel ok for the column?
2) What to use as eluent, DCM, EtOAcOH?
3) I suppose one would have to apply strong vac underneath the column?
4) How to figure out what fractions the psilocybin is in. I was thinking of some TLC(NMR is not an option)

Thanks!

Regards
Peter

[Rhodium]

https://www.thevespiary.org/rhodium/Rhodium/chemistry/psilo-tlc.txt

[lugh]

And

Post 176035

(lugh: "Re: psilocin", Tryptamine Chemistry)