That's a brute force method... Hard vacuum means oil pump vacuum. This will probably yield charcoal if done under water pump pressure.
Alternative methods to affect dequaternization are:
- boiling with triethanolamine (or was it ethanolamine?)
- or LiAlH
4 treatment.
UTFSE for previous posts on this here in the tryptamine forum.
It would be great if somebody could test the (tri)-ethanolamine route on substituted tryptamines
[hint]