A new method for making Methylaminorex (without CNBr) or PPA?
Some years ago I stumbled over the following syntheses:
If R1 is benzene and R is CH3 we would end up with 4-Methylaminorex and/or PPA!
I´m dreaming to take Isosafrol for this reaction (but I haven´t got some). This should be an interesting compound!
I could not get the original ref through my library. Maybe someone could post the text.
My question to all the chemists is: does the oxygen or the nitrogen moves to the benzylcarbon?
If this works, it could be an alternative method for making Methylaminorex without CNBr.
The orig. ref. is:
J.Takeda , S. Kuroda, J.pharm. Soc. Japan 1921, 467 ; 1921 I, 789