While reading around for more info on your previous post, I found this in March's 5th:
10-634:
Formation of Aziridines From EpoxidesIt is possible to prepare aziridines, which are synthetically important molecules, directly from the corresponding epoxide. Reaction of Ph3P=NPh with an epoxide in the presence of ZnCl2 gives the N-Phenyl Aziridine.
Kuhnau, D.; Thomsen, I.; Jorgensen, K.A.
J. Chem. Soc., Perkin Trans., 1 1996, 1167.As found in
March's 5th, pg. 515So one would need to use R3P=NCH3 with propylene oxide to make 1,2-dimethylaziridine.
How does one prepare compounds of the structure R3P=NR' ? Can these be purchased in a manner that is not like pulling teeth? i.e.Are they available for purchase or must they be custom synthesized, or even worse, prepared just before use, or even WORSE, prepared in situ?
[EDIT]Im a fucking dumbass sometimes, I swear. In the picture previously posted by MYSELF in this very thread, there is shown in big pictures how organic azides react with triphenylphosphine to form the compound needed above. The only real detriment is that lightweight (small M.W.) organic azides are explosives, so the methyl azide needed is a huge pain in the ass.[/EDIT]
[EDIT#2]In the route you propose, Rhodium, you say that cyclization would easily occur with the "tosyl ester." I assume you mean the tosyl ester of the alcohol, and not an N-tosyl group. Does that mean that tosic acid would need be used to form the tosyl ester, because tosyl chloride would replace the remaining proton on the nitrogen, preventing cyclization?[/EDIT]
PrimoPyro
Will perform sexual favors for females in exchange for 1,2-dimethylaziridine. PM for details.