perhaps a thermite, placed in a pit in the ground, over a mixture of fluffy wood chips and potassium nitrate and/or sulfur. A grille of chicken wire would cover this pit or bucket. Assuming one had a short while to act before the cops burst in, amine, ketone, and other incriminating products could be dumped in this hole and the thermite started (electrically), while one did the best job to hit the hills. The wood chips would soak up the organics, while the thermite and oxidizer would non-explosively do a job on the compounds one sought to destroy. It's certain one would still get busted, however, with the glassware smashed and most of the product destroyed, LE would have a much more difficult time proving how much you were making. This would probably cut much off one's sentence.
I think a special sink that went directly to the sewer, bypassing sink traps would be better in this respect. If one kept a scrupulously clean lab and had an oxidizer bath handy, it's possible one could avoid being caught with anything (i.e. only "pink-handed"). Wouldn't count on it, though.
If it were me, I'd avoid explosives. Kill or injure cops, and you will be impaled. Rather counterproductive....
Make analogs only for personal consumption instead. Give them a hard time to prove anything.