The Vespiary
The Hive => Chemicals & Equipment => Topic started by: Cyrax on June 06, 2002, 12:09:00 AM
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Is it suspicious to buy methoxyacetyl chloride? Is it a watched chemical?
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I'd say that is obscure enough to be safe.
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Methoxyacetyl chloride...
CH3-O-CH2-CO-Cl correct?
What use would this have clandestinely? Just curious.
PrimoPyro
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Well, you can use it instead of propionyl chloride or propionic anhydride to acylate 1-phenethyl-4-(N-phenylamino)-piperidine to get a nice fentanyl analog with an ED50 of 0.08 mg / kg. Propionyl chloride is suspicious (right?), so I think this is a good alternative.
Or you can use 2-furoyl chloride to the amine. That compound will certainly not be suspicious. Then the ED50 is 0.02 mg / kg.
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Cyrax: Very interesting! Refs?
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Very good idea!
Although somewhat weaker, you can get around U.K. generic definition (and maybe same in some other countries) ;)
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Check it out: US patent 4584303. You will find a real treasure of fentanyl analogs. It is one of the best fentanyl patents I have read.
Too weak: I think it is strong enough to not kill yourself during the synthesis. If you want a stronger compound: simply use o-fluoroaniline instead of aniline. Then the ED50 will be 0.0077 mg / kg. But I forsee that the yield of the acylation will be lower, since that lovely little fluorine atom will suck the free electron pair of the nitrogen into the aryl ring :) (resonance)