The Vespiary
The Hive => Methods Discourse => Topic started by: uncle_buck on September 23, 2002, 09:14:00 PM
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"Ephedrine from Benzaldehyde and D-L Alanine, Heat to yield CO2 + ephedrine."
Does this really work? Will pure l-isomer alanine work as well? Is it just the benzaldehyde and alanine in equimolar ratio or some other ratio? No solvent mentioned, so none needed, I suppose?
Thanks Hive gurus!
ub
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Hi!
I think you are confusing PPA and eph. By using the alanine + BA one will get PPA and not eph. To get eph you would have to use N-methyl-alanine, which is not so easy to come by as alanine.
As for solvent i belive you can find the answer by UTFSE.
Regards
Bandil
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PPA, gotcha. I will FS for the solvent info U'ing TE.
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use toluene or xylene as the solvent (although aurelius believes one may not be absolutely necessary- may even raise yeild) if picking between the two above, choose xylene, it has a higher boiling point (all three isomers are higher than toluene) and this allows for a better high boiling solvent for the decarboxylation that occurs at elevated temps.