I'd really like to know about the activity of 4-methyl PCP. It would be easy to synth from 4-bromo toluene, which itself could be made by bromination of toluene. I've looked into OTC prep of 4-bromotoluene, but I can't get hold of what seems to be the most promising paper:
Monobromination of aromatic rings using potassium bromide-sodium nitrate mixture in sulfuric acid.
J. Chem. Soc. Pak. (1992), 14(3), 212-14. CODEN: JCSPDF ISSN: 0253-5106. Journal written in English.
Abstract
A simple and rapid method for the selective monobromination of arom. rings involving the use of a mixt. of potassium bromide and sodium nitrate in sulfuric acid (60% vol./vol.) is described. Thus, PhMe was brominated by this method to give 70% 4-BrC6H4Me.
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It should be fairly easy to seperate any o-bromo toluene produced as a byproduct due to the differing melting points of the isomers. But I'd like to know the specific reaction conditions if possible. I don't suppose anyone has access to this journal and be willing to find out?