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Author Topic: removal of TBAF?  (Read 1929 times)

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blessed

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removal of TBAF?
« on: May 26, 2003, 04:36:00 PM »
Is there an easy way to remove tetrabutylammoniumfluoride (TBAF) or other TBA-salts from your rxn-product, in cases where recrystallisation won´t work (other than ion-exchange chromatography)??
This TBA-stuff sticks to my product all the way through extracting, washing, and more than one flash-silicagel-chromatography!
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Lilienthal

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Which product?
« Reply #1 on: May 26, 2003, 09:41:00 PM »
Which product?
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yellium

  • Guest
distillation?
« Reply #2 on: May 26, 2003, 10:09:00 PM »
distillation?
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blessed

  • Guest
produkt = 1,2-Biphenylacetylene
« Reply #3 on: May 26, 2003, 10:55:00 PM »
products = different 1,2-Biphenylacetylenes from two succeesing Sonogashira-rxn with TMS-Acetylen and aromatic iodides
TBAF was used for removal of TMS-Group after first Sonogashira-rxn(destillation seems unprobable, products are crystalline solids)
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slappy

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Silica gel should remove it.
« Reply #4 on: June 20, 2003, 12:02:00 AM »
Silica gel should remove it. Use the good 200mesh merck stuff. If that doesn't work, (I couldn't tell you why not)
use cation exchange resin.
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