[ 1 ] Generate the Caffeic acid Methyl Ester as this stops the coupling together of the caffeic acids with I-CH2-I at the -COOH
[ 2 ] Generate the methylene dioxy on the 3,4 - dihydroxy with I-CH2-I and K2CO3 as in Pihkal.
MDA SYNTHESIS
From MDCAME via Piperonal & Nitroethane - 4 steps. Directly from MDCAME - 5 steps.
Rhodium
Administrator posted 11-28-98 01:40 AM
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How would you suggest to go further from MDCAME?
Wizard X
Moderator posted 11-29-98 08:13 PM
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Directly from MDCAME - 5 steps.
Ph = methylenedioxy phenyl
Step 1 & 2 Make the nitro propenyl methyl ester
MDCAME + NO - NO2 ===>> (1) nitrosite
(1) + EtOH + NaOH ==>> ( 2 ) nitro propenyl methyl ester
Step 3 , Reduction of the nitropropenyl to an amino , ( -CH2- NH2 ) and the methyl ester to an hydroxy ( -OH )
Ph-CH2-CH(NH2)-CH2OH
Step 4 , Reaction with Tosyl chloride ( Tolulene-p-sulphonyl chloride ) on the OH & NH2
This forms the sulphonate ester and the sulphonate amide.
Step 5 , Reduction of the sulphonate ester and the sulphonate amide to give MDA