Post 353421 (missing)
(malvaxman: "4-bromoamphetamine", Chemistry Discourse)4-Fluoroamphetamine Doc (https://www.thevespiary.org/rhodium/Rhodium/chemistry/fluoroamphetamine.html)
(https://www.thevespiary.org/rhodium/Rhodium/chemistry/fluoroamphetamine.html) and that fact is also backed up inEur. J. Pharmacol. 287, 105-113 (1995) (https://www.thevespiary.org/rhodium/Rhodium/pdf/4-fluoroamphetamine.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/4-fluoroamphetamine.pdf)Spicy, if you dont mind me asking, how much would it cost if one were to replicate the same procedure, using the same quantities?
You know, I'm honestly not sure. A lot of the chemicals involved weren't purchased specifically for this project- For example, I bought 200-some odd grams of NaBH4 a long time ago, which wasn't cheap, but this synthesis used only a small portion of that. Solvents and related chemicals were also already on hand. Other reagents such as the 4-fluorobenzaldehyde itself and nitroethane, were basically acquired through trade with people that have better connections then I.
I do know one thing though, the cost of producing a mere 2.8 g would be comparatively outrageous compared to the price of producing say, 500 g, which is probably how wherever you may buy it from is making it.
Sorry!
-SpicyBrown
https://www.thevespiary.org/rhodium/Rhodium/chemistry/pfa.spicybrown.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/pfa.spicybrown.html)
https://www.thevespiary.org/rhodium/Rhodium/chemistry/4f-p2np.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/4f-p2np.html)
https://www.thevespiary.org/rhodium/Rhodium/chemistry/fluoroamphetamine.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/fluoroamphetamine.html)
and linked the above documents from that discussion.Post 422844 (https://www.thevespiary.org/talk/index.php?topic=9233.msg42284400#msg42284400)
(Bandil: "Verification of Bariums research", Methods Discourse)Post 422844 (https://www.thevespiary.org/talk/index.php?topic=9233.msg42284400#msg42284400)
(Bandil: "Verification of Bariums research", Methods Discourse), 2,5-dimethoxybenzaldehyde was used as the substrate. This is highly activate compared to 4-fluorobenzaldehyde, and gives much higher yields in the condensation reactions. That is most likely the reason that methylamine failed with 4-fluorobenzaldehyde.