Author Topic: Is this ephedrine synth really possible????  (Read 1457 times)

0 Members and 1 Guest are viewing this topic.

uncle_buck

  • Guest
Is this ephedrine synth really possible????
« on: September 23, 2002, 09:14:00 PM »
"Ephedrine from Benzaldehyde and D-L Alanine, Heat to yield CO2 + ephedrine."

Does this really work?  Will pure l-isomer alanine work as well?  Is it just the benzaldehyde and alanine in equimolar ratio or some other ratio?  No solvent mentioned, so none needed, I suppose?

Thanks Hive gurus!

ub

Bandil

  • Guest
I think you are mistaking
« Reply #1 on: September 23, 2002, 11:38:00 PM »
Hi!

I think you are confusing PPA and eph. By using the alanine + BA one will get PPA and not eph. To get eph you would have to use N-methyl-alanine, which is not so easy to come by as alanine.

As for solvent i belive you can find the answer by UTFSE.

Regards
Bandil

uncle_buck

  • Guest
Thanks for the clarification
« Reply #2 on: September 24, 2002, 03:22:00 PM »
PPA, gotcha.  I will FS for the solvent info U'ing TE.

Aurelius

  • Guest
solvent
« Reply #3 on: September 27, 2002, 09:52:00 PM »
use toluene or xylene as the solvent (although aurelius believes one may not be absolutely necessary- may even raise yeild)  if picking between the two above, choose xylene, it has a higher boiling point (all three isomers are higher than toluene)  and this allows for a better high boiling solvent for the decarboxylation that occurs at elevated temps.