The Vespiary

The Hive => Methods Discourse => Topic started by: ahgreich on June 24, 2003, 02:08:00 AM

Title: PPA from MEK and Benzaldehyde?
Post by: ahgreich on June 24, 2003, 02:08:00 AM

I have UTFSE until I'm BITF, but I clearly recall seeing some discussion re: cross-aldol condensation using mek+benzaldehyde to get ppa, or something very similiar to that reaction. Please help! am I delusional?

Title: No such thing.
Post by: Rhodium on June 24, 2003, 02:31:00 AM

You are probably confusing

Post 428632 (https://www.thevespiary.org/talk/index.php?topic=11523.msg42863200#msg42863200)

(Rhodium: "Piperonal + MEK -> Isosafrole?", Novel Discourse) with another post, possibly

Post 438325 (https://www.thevespiary.org/talk/index.php?topic=9020.msg43832500#msg43832500)

(Rhodium: "Norpseudoephedrine synthesis & optical resolution", Methods Discourse).

Title: I think you are thinking of this little gem by
Post by: BOS on June 26, 2003, 01:01:00 PM

I think you are thinking of this little gem by Twodogs:

Post 245942 (https://www.thevespiary.org/talk/index.php?topic=12139.msg24594200#msg24594200)

(twodogs: "New method for P2P", Novel Discourse) P2P, aldol, MEK, benzaldehyde ect. ;)
Nice aint it?

b

Title: Ahhh- BzH + Alanine -> ppa
Post by: ahgreich on August 15, 2003, 02:22:00 AM

Found the benzylaldehyde + alanine=PPA, seems simple with the exception of removing the benzylamine byproduct from the final product - What do bees think about P2P by taking the crude PPA with benzylamine , covering with toluene, hydrolyzing with H2S04/ZnCl,separating, and evapping the toluene? Will the benzylamine hydrolyze into anything that will be taken up in the toluene? Is this a reasonable route to P2P?

Title: Hey Driven
Post by: Aurelius on August 15, 2003, 06:06:00 AM

Have you seen this ?  Post your latest tests results- etc. 

(if you would that is)