From Merck:
6067. Methoxamine. .alpha.-(1-Aminoethyl)-2,5-dimethoxybenzenemethanol; .alpha.-(1-aminoethyl)-2,5-dimethoxybenzyl alcohol; 2-amino-1-(2,5- dimethoxyphenyl)-1-propanol; .beta.-hydroxy-.beta.-(2,5-dimethoxyphenyl)isopropylamine; .beta.-(2,5-dimethoxyphenyl)-.beta.- hydroxyisopropylamine; 2,5-dimethoxynorephedrine; C11H17NO3; mol wt 211.26. C 62.54%, H 8.11%, N 6.63%, O 22.72%. .alpha.1-Adrenergic agonist. Prepn: Baltzly et al., U.S. pat. 2,359,707 (1944 to Burroughs Wellcome). Metabolism: A. Klutch, M. Bordun, J. Med. Chem. 10, 860 (1967). Clinical pharmacology: N. T. Smith, C. Whitcher, Anesthesiology 28, 735 (1967); P. D. Snashall et al., Clin. Sci. Mol. Med. 54, 283 (1978). HPLC determn in plasma: I. A. Al-Meshal et al., J. Liq. Chromatog. 12, 1589 (1989). Therapeutic use: P. M. C. Wright et al., Anesth. Analg. 75, 56 (1992); L. Cabanes et al., N. Engl. J. Med. 326, 1661 (1992). Comprehensive description: A. M. Al-Obaid, M. M. El-Domiaty, Anal. Profiles Drug Subs. 20, 399-431 (1991).
Hydrochloride, C11H17NO3.HCl, Vasoxine (Burroughs Wellcome), Vasoxyl (Burroughs Wellcome), Vasylox (Burroughs Wellcome). Crystals, mp 212-216 deg. pKa (25 degC) 9.2. Very sol in water: One gram dissolves in 2.5 ml water, in 12 ml ethanol. Practically insol in ether, benzene, chloroform. pH of a 2% aq soln between 4.5 and 5.5.
THERAP CAT: Antihypotensive.
Yes, you're right, it is interesting.