Phenyl-2-Propanone oxime
J. Chem. Research (S) 24–25 (2000) (https://www.thevespiary.org/rhodium/Rhodium/chemistry/oximes.cao-nh2oh-hcl.html)
(https://www.thevespiary.org/rhodium/Rhodium/chemistry/oximes.cao-nh2oh-hcl.html)
Phenyl-2-Propanone (1.34g, 10 mmol) and finely powdered calcium oxide (5g, 89 mmol) was placed in a flask and heated in an oil-bath for a few minutes. Then hydroxylamine hydrochloride (2.08g, 30 mmol) was added, and the mixture was stirred with a magnetic stirrer in the presence of air for 1 minute at 130°C. Afterward, the reaction mixture was mixed with ethyl acetate, filtered to remove the calcium oxide, then mixed with water and extracted with ethyl acetate. The pooled organic phases was dried over Na2SO4, filtered and the solvent evaporated in vacuo to give phenyl-2-Propanone oxime (1.49g, 100%) in a syn/anti ratio of 9:1.