Author Topic: easy way to BOx style amphetamines?  (Read 2487 times)

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hypo

  • Guest
easy way to BOx style amphetamines?
« on: February 13, 2002, 12:46:00 PM »
1) dissolve 1-(X-phenyl)-2-propene in excess MeOH and gas with Cl2 at 0°C to get 1-methoxy-1-(X-phenyl)-2-chloro-propane (maybe Na2CO3 to catch H+ and remove Cl- as NaCl?)
2) finkelstein with NaI in acetone
3) NH3 in bomb

is this feasible or total bullshit?
one would get 2 out of 3 possible stereoisomers, right?

Osmium

  • Guest
Re: easy way to BOx style amphetamines?
« Reply #1 on: February 13, 2002, 12:56:00 PM »
You will add two chlorines across the double bond, not just one.

I'm not fat just horizontally disproportionate.

hypo

  • Guest
Re: easy way to BOx style amphetamines?
« Reply #2 on: February 13, 2002, 01:01:00 PM »
but why? according to my o-chem book the chloronium ion is intercepted by the nucleophilic MeOH (excess!) which adds to the more electro positive C, which is the one at the ring. they only say it works with H2O, but why not MeOH??

Osmium

  • Guest
Re: easy way to BOx style amphetamines?
« Reply #3 on: February 13, 2002, 01:05:00 PM »
Ooops! I overlooked that 1-MeO thingy!

Well, don't know.

I'm not fat just horizontally disproportionate.

Rhodium

  • Guest
Re: easy way to BOx style amphetamines?
« Reply #4 on: February 13, 2002, 03:05:00 PM »
Why not do it like in Pihkal? Addition of sodium methoxide to the phenylnitropropene?

hypo

  • Guest
Re: easy way to BOx style amphetamines?
« Reply #5 on: February 13, 2002, 03:12:00 PM »
because it's less otc and some people might have a phenyl propene which they have no use for...

Rhodium

  • Guest
Re: easy way to BOx style amphetamines?
« Reply #6 on: February 13, 2002, 03:14:00 PM »
The phenylpropene is turned into the nitropropene via the pseudonitrosite route, and sodium methoxide is definitely OTC with what Antoncho has posted recently.

PrimoPyro

  • Guest
Re: easy way to BOx style amphetamines?
« Reply #7 on: February 13, 2002, 03:20:00 PM »
Plain phenylpropene you say? No use you say? Wanna bee my new best friend? Try the photoamination of olefins with ammonium iodide catalyst, PTC, and a Xenon flash lamp, and report yields.  :)

                                                   PrimoPyro

The Water Will Be Your Only Mirror

hypo

  • Guest
Re: easy way to BOx style amphetamines?
« Reply #8 on: February 13, 2002, 03:22:00 PM »
yeah ok, but for the pseudonitrosites you need NaNO2 which is not available everywhere, so make that from NaNO3. the NaOMe has to be made and the resulting nitropropane has to be reduced (how?). otoh, getting some practice with pseudonitrosites may not be that bad.

hypo

  • Guest
Re: easy way to BOx style amphetamines?
« Reply #9 on: February 13, 2002, 03:23:00 PM »
pp: no plain phenylpropene.  :P