Author Topic: Cl -> OH  (Read 3272 times)

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Natrix

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Cl -> OH
« on: September 24, 2001, 10:44:00 PM »
How difficult would it be to make 2-methyl-hydrochinone from 4-chloro-3-methylphenol (PCMC) ? PCMC is a biocide and is used against bacteria, fungi and yeast.
 

PolytheneSam

  • Guest
Re: Cl -> OH
« Reply #1 on: September 24, 2001, 11:12:00 PM »
I saw something in a chemistry book about a Dow Chemical process for making phenol from chlorobenzene using NaOH solution at 350 degrees C under pressure.

http://www.geocities.com/dritte123/PSPF.html

Rhodium

  • Guest
Re: Cl -> OH
« Reply #2 on: September 24, 2001, 11:13:00 PM »
Reflux in strong sodium hydroxide solution together with copper powder, for at least 24h.

A general method is described for 5-hydroxyvanillin in:

https://www.thevespiary.org/rhodium/Rhodium/chemistry/mmda.mescaline.html



If you were planning on using it for 2,5-dimethoxytoluene, I'd suggest you methylate the starting material first, for easier workup, and possibly better yields.

Natrix

  • Guest
Re: Cl -> OH
« Reply #3 on: September 25, 2001, 12:22:00 PM »
Thanks for your answers PolytheneSam and Rhodium.  Although the yield might be low (US.P. 3,778,481), the substance is very interesting because it is sold otc and it is inexpensive. 

foxy2

  • Guest
Re: Cl -> OH
« Reply #4 on: September 25, 2001, 05:40:00 PM »
If you have access to an ultrs sonic bath I would put the reaction in it periodically.  It should increase yeilds

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