to ketamine.. Anybody want to guess if this will work? I'm guessing at 180'c it will disolve the amide fine, but the methods I've come across either use decalin, undecane, or gas ethyl benzoate with HCl. Does it matter that DMSO is aprotic? Will DMSO favour the thermal rearangement? What would be the best way to extract the amine from DMSO? Could it be done up by adding water and extracting with DCM/toulene? I do not think DMSO/water would solvate the freebase very well at all. DMSO is more readily and cheaply available then undecane, decalin, and ethyl benzoate.
link to DMSO info, including solubility and rxn info: http://www.gaylordchemical.com/home/default.asp (http://www.gaylordchemical.com/home/default.asp)
I'm refering to the amide, before the final step of thermal rearangement to the drug commonly called ketamine. ketamide seems appropriate enough scince ketamine is no more specific of description of the common drug. Although, the diagram (https://www.thevespiary.org/rhodium/Rhodium/chemistry/pcp/pictures/ketamine_synth.gif)
(https://www.thevespiary.org/rhodium/Rhodium/chemistry/pcp/pictures/ketamine_synth.gif) refers to a ketone that does not appear to be what is drawn.
I'm refering to the following examples:
https://www.thevespiary.org/rhodium/Rhodium/chemistry/ketamine2.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/ketamine2.html)
https://www.thevespiary.org/rhodium/Rhodium/chemistry/pcp/ketamine.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/pcp/ketamine.html)
Nevermind found it, although that isn't really any practical info. Heating a few 100mls of kerosene to 180'c is a little different then heating 50l of it, and as k0dog says there are much more practical ways of producing the salt from the freebase. IPA seems to be the best solvent to use, and EtOH seems to work well to recrystalize. But no doubt the people getting rich of ketamine freebase weren't too keen to share their secrets prior to legal changes in china.
Will DMSO dissolve the imine better then the amine? Can anyone tell me that? Based on page three, four of this (http://www.gaylordchemical.com/bulletins/bulletin116.pdf)
(http://www.gaylordchemical.com/bulletins/bulletin116.pdf) info will it hinder the thermal rearangement?