http://rhodium.lycaeum.org (http://rhodium.lycaeum.org)
I just had a look into several books but I couldn't find Weinrab mentioned anywhere so I guess a bit. Weinrab amide = ...dimethylamide ?
WeinrEb amine = N,O-dimethylhydroxylamine. Condense with a suitable carboxylic acid derivative and you've got a WeinrEb amide.
Dimethylamides react with grignards to produce dimethylamine and a new carbonyl-compound.
This does not cleanly give ketones unless a huge excess of the amide is used, if at all. Thus, if the amide is the limiting reagent(as in this case), your yields would suck ass. With the Weinreb amide, low tempetature addition of a slight excess of the grignard or organolithium reagent usually gives a 80-95% yeild of the ketone.
So if this is what we are talking about then why not use BzMgCl and N,N-dimethylacetamide to get P2P ?
That's not what he was talking about.