This is my first post to the hive. I am curious about PMA/PMMA analogs and have found a few references on rhodium's site, here, and in PIHKAL that I think could apply to PMA. I might be wrong though and would appreciate any advice. If I
have any dreams that seem realistic enough I'll try to start a PMA analog daydreamer's FAQ.
#1 Nitro-PMA/PMMA
A solution of 7.1g PMA (or 7.7g PMMA) base in 40mL acetic acid was added dropwise over the course of 0.5 hrs to 43mL of 50% nitric acid which was well stirred and cooled with an external ice bath. The resulting solution was quenched with ice water, made basic with aqueous NaOH, and extracted with a non-polar solvent. Dry, Gas, Recrystalize, give .25mg to your neighbors dog, see if he dies, then start upping the dose.
This proposed synthesis was based on Shulgin's DON synth (http://www.erowid.org/library/books_online/pihkal/pihkal070.shtml)
(http://www.erowid.org/library/books_online/pihkal/pihkal070.shtml)
In it he mentioned acetamide and formamide derivatives. Were these formed later as another synthesis or during this reaction? How could a kitchen chemist accompish the hydrolysis?
#2 Iodo-PMA/PMMA
There are two documents on rhodiums site that I thought could be used: https://www.thevespiary.org/rhodium/Rhodium/chemistry/doisynth.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/doisynth.html)
describes a very specific synthesis of 3-iodo-PMA but uses expensive and uncommon silver sulfate whereas https://www.thevespiary.org/rhodium/Rhodium/chemistry/aromatic.iodination.i2-nitrate.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/aromatic.iodination.i2-nitrate.html)
uses sodium nitrate (cheaper and easier to get), but is written for anisole. Would this work on PMA? Also, it lists the product as 4-iodoanisole.
Where on the PMA would the iodine end up? On the ring? which position?
#3 Bromo-PMA/PMMA
33.3g PMA (or 36.1g PMMA) is dissolved in 500mL of a 3:1 acetone/dH2O solution. The RXN is cooled to 0C in an icebath with magnetic stirring. 37.3g of 48% HBr(aq) was added, followed immediately by 23.8g H2O2. the RXN was stirred for six hours, allowing the ice bath to melt. The acetone is removed under vacuum and the residue is dissolved in 0.5-1L dH2O. The aqueous solution is washed with non-polar solvent (ethyl acetate, toluene, ether), basified to pH 12 with aqueous NaOH, and extracted with 3x200mL portions of ether. The combined extracts are washed with brine, H2O, and dried over MgSO4. Gas, filter, and recrystalize from IPA/Toluene
This was based on the bromination step in beaker's 2C-B synth, thanks. It would be nice to find a synthesis using NaBr, H2SO4, and H2O2. I know it would work but dont know the amounts.
I would test out these drugs by dissolving 1.00g in 100 "units" of a 1cc syringe. Expel all but 10 units, refill and repeat. Each unit now contains 0.1mg
I believe you are referring to this document: https://www.thevespiary.org/rhodium/Rhodium/chemistry/fluoronitro.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/fluoronitro.html)
Would you describe the general effects as euphoric, psychedelic, or merely an intoxicated feeling?
I'm abit weary of experimenting with these compounds myself ever since I got migraine headaches from normal doses of PMMA.
What I have been pondering on is N-ethyl-PMA. Has anyone tried this yet?
This is just some loud thinking, but if you look at the PMA molecule, and you compare it with tyramine, one notices that PMA is tyramine with an alpha-methyl group which blocks breakdown by MAO enzymes, and an added methyl ether to help it pass the bloodbrain barrier. So one could speculate that PMA gives exactly the effects that people using MAO-inhibitors want to avoid.
Monoamine oxidase enzyme usually also breaks down tyramine. If an MAO-inhibitor is used, tyramine is not broken down as it usually is, and levels of this chemical build up. Tyramine causes elevation of blood pressure, so an increase in this chemical leads to an increase in blood pressure which could lead to stroke, heart attack, and other nasty side effects. Because of this, people using MAO-inhibitors must avoid foods that are high in tyramine, such as alcohol, legumes (e.g., fava and soy beans), cheese, fish, ginseng, meat, sauerkraut, shrimp paste, soups, and yeast extracts (baking yeast is OK in small quantities).
http://www.afraidtoask.com/depression/depressionmao.htm (http://www.afraidtoask.com/depression/depressionmao.htm)
It might be a good idea to avoid above foods too when experimenting with it, or with its analogs.