The Vespiary

The Hive => Methods Discourse => Topic started by: Grignard on March 30, 2004, 12:55:00 PM

Title: cocaine from tropinone
Post by: Grignard on March 30, 2004, 12:55:00 PM

Title: UTFSE!
Post by: Rhodium on March 30, 2004, 01:46:00 PM

It was too hard to UTFSE, I suppose? The following thread is among the top 20 in this forum even:

Post 477883 (missing)

(Rhodium: "Practical Total Synthesis of Cocaine", Methods Discourse)

Title: yes a lot of references there, but i dont find
Post by: Grignard on March 30, 2004, 04:44:00 PM

yes a lot of references there, but i dont find an answer on how to make Methylecgonine from tropinone.. In this old text they reduce tropinone with raney Ni, Is this a process that will work and under what yield? it is this reference i would like to see...

Title: did you read the whole thread?
Post by: Rhodium on March 30, 2004, 05:13:00 PM

The Findlay paper here converts tropinone to 2-carbomethoxytropinone:

Post 488336 (https://www.thevespiary.org/talk/index.php?topic=8911.msg48833600#msg48833600)

(Rhodium: "Synthesis of Tropinone & 2-CMT", Methods Discourse)
And the links at the bottom of the page concerns the reduction of the latter to methylecgonine. The papers in

Post 487702 (missing)

(Rhodium: "Willstätter's Classic Cocaine Synthesis", Methods Discourse) also details the procedure.

Title: cocaine from tropinone
Post by: roger2003 on March 31, 2004, 05:02:00 AM

See:

Patent DE406215 (http://l2.espacenet.com/dips/viewer?PN=DE406215&CY=gb&LG=en&DB=EPD)