P2P - new idea.
See it in Russian:
Post 378325 (missing)
(fallen_Angel: "P2P - íîâàÿ èäåÿ.", Russian HyperLab)Recently I have invented brand new a path of synthesis P2P
Response:
1. 2Na + 2NH3 - > 2NaNH2 + H2
2. NaNH2 + HCCH - > HCCNa + NH3
3. C6H5CH2Cl + HCCNa - > C6H5CH2CCH + NaCl
4. HgSO4
C6H5CH2CCH + H2O - > C6H5CH2COCH3
Or
4 (a). C6H5CH2CCH + HBr - > C6H5CH2CBr2CH3
5 (b). C6H5CH2CBr2CH3 + NaOH - > C6H5CH2COCH3 + 2NaBr
The first 3 stages - response in one vial.
4 stages - good known response Kutcherov
4 (a), 5 (b) - optional versions.
In 3 and 4 stages are guessed high (not less than 80 %) yields. This method very simple, all reagents - benzyl chloride, ammonia and calcium carbide (acetylene) OTC, about sodium - whom as, sulphate of quicksilver made be easeli. Quicksilver you are purchase radioshops, where there is a lot of cheap quicksilver.
For deriving sodium amide it is not necessary to take fluid(liquid) ammonia, though all you need is a dry ice and artful cooler - tube a dia of centimeter 3-4 and lengthy 40-50 cms, second soldered from one endb a dia 2-3 cms, is interposed in first. In interior the dry ice is filled in and a little acetone is flooded. In the device the gaseous ammonia is passed, he condences and flows down in a flask.
Though probably it is easier sodium amide to receive, passing ammonia above heated sodium.
Response 3-phenil-1-propyne with water - we add the catalytic agent and is boiled with a reflux condenser, and then distillate phenilaceton with steam.
And more:
We to pulp carbide in a dust, we add benzyl chloride (or its solution?):
CaC2 + C6H5CH2Cl - > C6H5CH2C2CaCl
Then we add water, we receive 3-phenil-1-propyne..
Interesting idea, and sodium is not necessary, and generally ÎÒÑ
Problems:
1. At deriving 3-phenil-1-propyne generally, there is a migration of acetylene bond or formation of cyclic yields?
2. In case of migration of bond
C6H5CH2CCH - > C6H5CCCH3
The response Kutcherov with formation P2P or propiophenone will work? It is very important for knowing for further operation. On atom of carbon, adjacent with a benzene ring some negative charge will be , that allows to go with formation P2P, but practically I do not know.
3. There will be a response of benzyl chloride immediately with carbide? What solvents it is better to use?
4. Is it possible to use instead of fluid ammonia diethyl amine, or other amine? It would simplify a method.
Fallen_Angel