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Author Topic: cocaine from tropinone  (Read 3827 times)

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Grignard

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cocaine from tropinone
« on: March 30, 2004, 12:55:00 PM »
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Rhodium

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UTFSE!
« Reply #1 on: March 30, 2004, 01:46:00 PM »
It was too hard to UTFSE, I suppose? The following thread is among the top 20 in this forum even:

Post 477883 (missing)

(Rhodium: "Practical Total Synthesis of Cocaine", Methods Discourse)

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Grignard

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yes a lot of references there, but i dont find
« Reply #2 on: March 30, 2004, 04:44:00 PM »
yes a lot of references there, but i dont find an answer on how to make Methylecgonine from tropinone.. In this old text they reduce tropinone with raney Ni, Is this a process that will work and under what yield? it is this reference i would like to see...
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Rhodium

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did you read the whole thread?
« Reply #3 on: March 30, 2004, 05:13:00 PM »
The Findlay paper here converts tropinone to 2-carbomethoxytropinone:

Post 488336

(Rhodium: "Synthesis of Tropinone & 2-CMT", Methods Discourse)
And the links at the bottom of the page concerns the reduction of the latter to methylecgonine. The papers in

Post 487702 (missing)

(Rhodium: "Willstätter's Classic Cocaine Synthesis", Methods Discourse) also details the procedure.

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roger2003

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cocaine from tropinone
« Reply #4 on: March 31, 2004, 05:02:00 AM »
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