I have two questions about two methods of decarboxylation:
https://www.thevespiary.org/rhodium/Rhodium/chemistry/tryptophan.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/tryptophan.html)
- Decarb in diphenylether
Is it really necessary that this reaction is carried out under nitrogen(inert) atmosphere? If it does, do you have any tips for doing this when you don't have a cylinder of N2?
- Decarb in cyclohexanol with 2-Cyclohexen-1-one katalyst.
Does anyone knows a way to make this one? I searched the forum and Organic Syntheses but found nothing?
Some kind of partial dehydrogenation of cyclohexanone?
2-Cyclohexen-1-one can be found as an impurity in technical grade cyclohexanol, so running the decarboxylation in cheap-ass refluxing old cyclohexanol will work.
Reference:
A Novel Decarboxylation of alpha-Amino Acids
M. Hashimoto
Chem. Lett., 893-896 (1986) (https://www.thevespiary.org/rhodium/Rhodium/chemistry/trp.decarbox.enone.html)
(https://www.thevespiary.org/rhodium/Rhodium/chemistry/trp.decarbox.enone.html)