The Vespiary
The Hive => Newbee Forum => Topic started by: tryin on March 21, 2004, 07:05:00 AM
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Has anyone tried to synth AL (Phikal #2)? It seems to me that the most difficult part would be:
"A suspension of 4.0 g LAH in 150 mL anhydrous THF under N2 was cooled to 0 °C and vigorously stirred"
Is there an alternative to this step? The chemicals are very toxic, and hard to acquire. Any help is much appreciated.
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if you have to ask, then it is probably too hard for you.
what you need is a route to syringaldehyde (utfse) or buy it,
then alkylate (utfse) it with allyl iodide or bromide (utfse),
then do a nitromethane condensation (utfse) also called henry
reaction (utfse) and then do one of the various nitrostyrene
(utfse) reductions, for example with Zn (utfse) or Al/Hg and
NaBH4 (utfse). and then pray that the allylic double bond is
not reduced.
honestly: start with something more simple where the aldehydes
are more readily available (2C-B (utfse), Mescaline (utfse))
;) ;)
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I'm not so sure, hypo...
If ning were to make something like that, (mind ye, mescaline is something special) the fact of the matter is, allyl chloride/bromide may just bee easier for our bee here to make than methyl iodide or whatever s/he would use to make 3,4,5-TMB. And though I'm not so sure 'bout it, last I heard allyls were pretty tough buggers, and if something harsh as hell like LiAlH4 wouldn't touch it, I bet not much else our bee would throw at it would either.
Tryin, consider using EtBr as well. That's REALLY otc.
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my point was that the aldehydes for mescaline and 2c-b can be bought.
you are right about the allyl chain though - will probably survive.