The Vespiary

The Hive => Methods Discourse => Topic started by: psycosmo on May 06, 2002, 10:40:00 PM

Title: Phenethylamine via Leuckart
Post by: psycosmo on May 06, 2002, 10:40:00 PM

Anybody see any reason why phenethylamine couldnt by made from phenylacetealdeyde use the Leukart Reaction with formamide and formic acid?

Title: PhCH2CHO
Post by: Rhodium on May 06, 2002, 11:40:00 PM

Phenylacetaldehyde polymerizes easily, and the Leuckart reaction involves high temperatures and harsh reaction conditions, so it is very possible that the yield from such a reaction wouldn't be especially appealing.