Hydrocodone

[roddyjojo]

https://www.thevespiary.org/rhodium/Rhodium/chemistry/dihydromorphinones.html

Regarding the text available at the posted link, and the codeine -> dihydrocodeinone (hydrocodone) by rearrangement, can Nickel (Nickel metal or Nickel on Aluminum) be used in place of Pd/Pt in this reaction? I've read somewhere that it can but at some sacrifice to yields, however cannot recall the source.

Also if a powdered mixture of Nickel and Copper and roughly evening amounts was used, how would the presence of the Copper affect the reaction?

Thanks

[bouncer]

Has anyone done such synth: codeine -> dihydrocodeinone (hydrocodone) ? It seems as it would be very mg efficient (less hydrocodone is needed than codeine to achieve euphoria)

[algebra]

No - do more reading...

LoneR says that Pd in dry toluene (rather than acidic aqueous solution) yeilds 30% (see alt.d.c). note even rapoport was apparently unable to replicate this hydrogenation/dehydrogenation to obtain the hydrogenated ketone with any kind of yield.