SWISA needs to know if this recipe has anything wrong with it. READ CAREFULLY:
To a 5L 2-neck flask equipped with condendor and addition funnel goes:
-100gm safrol
-5gm Palladium Chloride
-250ml methanol
Commence with the magnetic stirring full bore while bringing temp to 80c.
-over 30 minutes time frame,start adding H2O2 when temp
reaches 78-80C.
Maintain reflux at 78-82C for a TOTAL of 6 hours.
Flood with dH2O and clean up with solvent (DCM, toluene, etc)
The original synthesis was found in TSII but used Tert-butyl alcohol instead of MeOH and Palladium acetate instead of Palladium Chloride.
Are these modifications realistic if one wants to yield the precoius oil (smells to ketone)?
Assrash Ouch!