From Helvetica Chemica Acta of volume. 26, 944-65 (1943). D-Isolysergsaeure-hydrazid won ethereal solution of the azide one shifted one from 1.0 g with 3.0 CC. Dia. ethyl amine, reinst (Merck), and left untouched with 20°C uber night. The condensation product consisted of a mixture of Lysergsaeure and Isolysergsaeure diaethylamid, which did not krystallisierte and could only by chromatographische adsorption be divided. One loosened the substance in little chloroform, which contained 1% alcohol, adsorbed with alumina after breaking into man and developed the two zones with the same solvent. The fast moving the portion into the filtrate resulted in in the case of evaporation arrears of 0.5 g with [ a]20/D=+84° (c=0.15 in Pyridin), the more slowly moving zone 0,11 g with [ a]20/D=+168° (c=0.15 in Pyridin). Since none of the two parliamentary groups krystallisierte, they were subjected to the adsorption analysis separately again, but this time using of benzene acetone 9:1 as solvents. The parliamentary group with [ a]20/D=+84° could be divided thereby again into two zones, which supplied now both krystallisierende evaporation jerk conditions. The faster moving parliamentary group (0,22 g) krystallisierte from chloroform when diluting with ether. Umkrystallisieren from benzene supplied course-sharpened prisms with the Smp. 80-85°C. The specific Drehvermogen, [ a]20/D=+30° (c=0.44 in Pyridin) showed that D-Lysergsaeure-diaethylamid had to be present. The more slowly moving zone of the parliamentary group +84° resulted in a krystallisierten eindampfrueckstand, which was identical with the Krystallisation from the second adsorption analysis the parliamentary group +168°, and which contained the amide of the Isolysergsaeure row. By Umkrystallisieren from acetone, from which the substance in beautiful prisms separates, D-Isolysergsaeure-diaethylamid one kept pure. Smp.182°C (under decomposition).
Helv. Chim. Acta 26, 944-965 (1943) (https://www.thevespiary.org/rhodium/Rhodium/pdf/lsd-25.hofmann.pdf)
(https://www.thevespiary.org/rhodium/Rhodium/pdf/lsd-25.hofmann.pdf)