The Hive > Stimulants

why iso..??

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UncleFester:
Is pseudo sulfate difficult to get dissolved in alcohol? If so, a bit of HCl in the extraction alcohol might help....otherwise I can see no reason why pseudo sulfate pills wouldn't behave in a similar way...

Urban_XTC:
meth-hcl is soluble 1:5 in chloroform, does pseudo have thet same property, if so what about the new gakks, just a thought

UncleFester:
This one takes me back to wher I started on this subject a year ago in the Pill Fuckers at it Again thread.
Gas station ephedrine pills were ground up in a blender with no solvent pre-soak. They were then extracted with portions of 91% isopropyl alcohol. This pill formulation turned out to be a filter clogging type, so after soaking and swirling, it was allowed to settle and the soak was decanted. Then several more alcohol soaks were done over a period of several hours. This resulted in a milky looking solution that was allowed to settle overnight.
   The almost clear alcohol extract was poured off the settled debris, and put into a beaker. It was put on the stove at med heat and set to boiling. As it got warm, roughly 12 grams KOH per 100 of the 25 mg ephedrine plus 200 mg guifenesin pills was added.
As it got boiling, the initially kind of clear solution turned a pale yellow, then a yellow oil layer formed at the bottom of the beaker. There was a fairly large amount of the oil compared to a similar number of sudafed pills. Boiling was continued for 25 minutes.
When the beaker had cooled down, the liquid was poured into a sep funnel. The oil layer was drained off, and the alcohol put back into a beaker. It was slowly evaporated down. The alcohol was of a kind of cloudy appearance.
When the alcohol was almost all gone, roughly 70 ml of water was added to the beaker for each 100 pills used. It was swirled around to dissolve the stuff at the bottom of the beaker, and poured into a sep funnel. Then about 50 ml of naptha (actual solvent used:hexane)was put into the beaker to clean up some more. This wash was put into the sep funnel as well.
The sep funnel was shaken, and after a bit of time to let the layers settle, the water was drained off. This was followed by another water wash, which too was drained away.
Finally, the naptha(hexane) layer was poured into a beaker, allowed to sit for a couple hours to shed water, then poured into another beaker and gassed with dry HCl. Yield roughly 70% of what seems to be nice ephedrine HCl. Perhaps it is time to start with recrystallization experiments.

wareami:
UncleFester: I'm not sure of the relevency here or if this might help but IPA is used to make eudragit and while the KOH is proven to deal with that part, my thought is that if another alky was used as the extractant, the KOH part wouldn't bee overburdened as much.
If you get my drift.
I could be wrong about that but it's just a hunch.
Maybe Denat or methanol might improve yields and reduce that milkiness.

UncleFester:
Those gas station pills were the ones which a year ago got me interested in these new pill formulations. They were the WORST ever seen. If the KOH method should fail on them, one wouldn't want to be wondering if it was because of a switch to different alcohol type.
I have no idea if 95%EtOH is as good or better than 91% iso. That would make an interesting line of experimentation.

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