this one looks like it might leave the MD bridge intact, and the opiate chemists been holding out on ya
Known methods of converting codeine to morphine by demethylation (codeine is morphine 3-methyl ether). Cleavage of aromatic ethers are commonly effected by reflux with concentrated HBr or HI. This relatively simple method can unfortunately not be used on codeine, as the oxygen bridge at the 9,10 position on the morphinan carbon skeleton would also rupture, causing the rearrangement of the molecule to the very potent emetic apomorphine, completely devoid of opiate-like effects.
5) Using L-Selectride (Lithium tri-sec-butyl Hydride) [6,7] 482 mg (1.6 mmol) of codeine was dissolved in 4 ml of an 1 M solution of L-selectride in THF (4.0 mmol) and was refluxed for 3.5h. The reaction was quenched with water (5ml), followed by 2ml of 15% NaOH solution and removal of the THF. The resulting mixture was washed twice with CH2Cl2, cooled to 0-5°C and acidified to pH 1 with 10% HCl. After basification with ammonium hydroxide to pH 9, the mixture was extracted into CHCl3, the organic phase was washed with brine and dried over Na2SO4. Removal of the solvent, followed by recrystallization from water gave 355mg (73%) of morphine hydrate. Unreacted codeine was recovered from the non-phenolic extracts, and after purification by recrystallization from water, it amounted to 71mg (14%). The method i have suggested and outlined works well in the lab if the required reagents are attainable, there are easier ways i can think of to performing this convertion but for obvious ethical and moral reasons i have not placed this information on to this page to prevent any negative use of my knowledge.
http://www.geocities.com/taylex18/ (http://www.geocities.com/taylex18/)
this one looks promsing to avoid cyclisation, and possibly MD cleavage, as well seems to inhibit AlCl3 from bonding to and cleaving oxygen atoms. and to make it even sweeter it lives next door to otc, (reduce your DMSO to DMS with Al/Hg and simply bubble the evolved DMS into your DCM :) . similar rxns without DMS involved cyclisation
Osthenol(condensed version)
DMS (2,5ml) added to a suspension of anhydrous AlCl3 (0.33g, 2.5mmol) in CH2Cl2 (5ml) at 0degC with stirring until in solution. to this solution, osthol (0.24g, 1,0mmol) was added over 10 minutes at same temp. Allow temp to reach RT and stir 24hours, rxn was quenched in 1N HCl and extracted with CH2Cl2 and purifiied on column, yeild 62%
Molecules 2000, 5, 880-885, Gopalakrishan, Kasinath
www.mdpi.org
is this what you meant by mild? any other got an opinion of whether or not these rxns would be sufficient to the task?
as in cobalt