Following the Jacobs Method of Alkaloid Hydrolysis - at the end:
The lysergic acid was dissolved in Warm MeOH and then cooled to 0 C and the crystals precipitated.
- White and grey crystals precipitated after allowing to sit at 0 C for 12 hours. The crystals were then filtered off. Fortunately, the MeOH was put back in 0 C for 24 hours and again crystals precipitated - they were filtered. This was repeated again with the same result, Although the amount has decreased each time.
? - Is it normal that it should take so long for this precipitation to occur - from this, does it make more sense to leave the solution at 0 C for several days until all the precipitation has occured?
Second Question,
Using the CDI method for LA to LSD. What are the drawbacks to running this procedure with a small amount of LA other then working with small weights etc.
Example. If you have 0.1 grams of LA - can you still run the procedure or is there a size of reaction that limits this process?
Thanks anyone that can help!!