The Vespiary

The Hive => Newbee Forum => Topic started by: ekolo on December 08, 2003, 11:31:00 PM

Title: Oxidation of Aldehydes
Post by: ekolo on December 08, 2003, 11:31:00 PM: I learned something about the O2 wacker its the wacker by spiceboy found on rhodiums site
https://www.thevespiary.org/rhodium/Rhodium/chemistry/wacker.krv.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/wacker.krv.html)

i found out that if i do the wacker where you use: 1 g PdCl2
6 g CuCl2
250 ml denatured alcohol
50 ml ultra clean, vac distilled safrole
in the SRV. you will get mdp2p but you need to destil it now comes the tricky part in your crude mdp2p you have MDP3P(The reaction produces a 85:15 mixture of MDP2P and "MDP3P) thats bad now you can oxidize the aldehyde to remove it and then wash it away with aqueous bicarbonate from the unchanged MDP2P. now i dont know much about this and stil dont know much, ive read but there is not much about it i would just like to know if there is someone out there with the nessesary know how.
btw. what would happen if i destiled my ketone and got the mdp3p with it, what would happen with the end product.
Title: Re: oxidation of aldehydes
Post by: java on December 09, 2003, 01:45:00 AM: I once read that if in your reaction you got two products such as you have the aldehyde can be oxidized with Potassium dichromate and then salt it out with 10% aqueous sodium carbonate . The result would be your untouched desired product without beign affected. I think it had to do with the inability to steam distallating the one from the other because of the closeness of the temp of sublimation of both.

I remember now it was with the synthesis of P2P via 2-phenylpropanal once the reaction occurs with H2SO4 and cooled and separated with toluene the product is a combination of 2-phenylpropanal(an aldehyde) and P2P. Then it was there that the comment was made ....about what I just told you........java
Title: 3-(3,4-Methylenedioxyphenyl)-propyl-methylamine
Post by: Rhodium on December 10, 2003, 12:15:00 AM: btw. what would happen if i destiled my ketone and got the mdp3p with it, what would happen with the end product.

Post 438347 (https://www.thevespiary.org/talk/index.php?topic=10543.msg43834700#msg43834700)
(Rhodium: "3-(3,4-Methylenedioxyphenyl)-propyl-methylamine", Newbee Forum)
Title: ok THX
Post by: ekolo on December 14, 2003, 09:23:00 PM: ok lets call this (mdp3p)impurity a problem now thoes this problem find place in the whole Wacker KRV - Ketone's Guide to Wacker-powered Production of MDP2P
found at rhodiums site. there are 3 methodes in
https://www.thevespiary.org/rhodium/Rhodium/chemistry/wacker.krv.html (https://www.thevespiary.org/rhodium/Rhodium/chemistry/wacker.krv.html)
one of them is producing some impurity what about the other two thx.
Title: MDP3P
Post by: Rhodium on December 14, 2003, 10:08:00 PM: It is very likely that all wackers produce MDP3P to some extent, and as the "three methods" in the document you mention are all variations of the O₂ Wacker in an alcoholic solvent, they are unlikely to differ. Only when you change the solvent, the catalyst or the oxidant you can expect any changes in product selectivity.
Title: hehe ok thx for the help.
Post by: ekolo on December 14, 2003, 10:25:00 PM: hehe ok thx for the help.
Title: btw what is LD50 for the MDP3P formed by o2...
Post by: ekolo on December 15, 2003, 10:55:00 PM: btw what is LD50 for the MDP3P formed by o2 wackers just a question.
Title: I don't think that has ever been determined.
Post by: Rhodium on December 16, 2003, 05:36:00 PM: I don't think that has ever been determined.
Title: hmm ok thanks chief :-)
Post by: ekolo on December 17, 2003, 12:13:00 AM